![]() Thus, osteoclasts recycle via osteomorphs, a cell type involved in the regulation of bone resorption that may be targeted for the treatment of skeletal diseases. ![]() fission and cisplatin sensitivity in vitro and in vivo.133This means a. The word 'dysregulation' is a neologism created by combining the prefix 'dys-' to 'regulation'. Furthermore, genetic variation in human orthologs of osteomorph genes causes monogenic skeletal disorders and associates with bone mineral density, a polygenetic skeletal trait. In addition, miRNAs were dysregulated in A549DOX11 cells compared with A549 cells. Single-cell RNA sequencing showed that osteomorphs are transcriptionally distinct from osteoclasts and macrophages and express a number of non-canonical osteoclast genes that are associated with structural and functional bone phenotypes when deleted in mice. Inhibiting RANKL blocked this cellular recycling and resulted in osteomorph accumulation. Here, by intravital imaging, we reveal that RANKL-stimulated osteoclasts have an alternative cell fate in which they fission into daughter cells called osteomorphs. Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/macrophage-derived precursors that are thought to undergo apoptosis once resorption is complete. During neoplastic progression, cellular senescence is bypassed by the inactivation of cell cycle checkpoint genes such as p53 and pRb.10 With continuing cycles.
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